A baicalin-loaded coaxial nanofiber scaffold regulated inflammation and osteoclast differentiation for vascularized bone regeneration

We demonstrate a simple, effective and feasible method to address the shrinkage of Poly (lactic-co-glycolic acid) (PLGA) through core-shell structure fiber strategy. The results revealed that introducing size-stable poly-caprolactone (PCL) as core significantly improved PLGA-based fibrous scaffold's dimensional maintenance. further utilized fish collagen modify PLGA shell layer (PFC) coaxial fibers loaded baicalin (BA) into PCL (PCL-BA) endow scaffold with more functional biological cues. PFC/PCL-BA promoted osteogenic differentiation bone mesenchymal stem cells stimulated RAW264.7 polarize pro-reparative phenotype. Importantly, in vivo study demonstrated could regulate inflammation osteoclast differentiation, favor neovascularization formation. This work tactfully combined establish drug release platform based on for vascularized regeneration.